实验细胞资源平台通过国家认定.doc

BIOGRAPHICAL SKETCHNAMEXiaojing MaeRA COMMONS USER NAMExiaojingmaPOSITION TITLEProfessor (tenured)Weill Medical College of Cornell UniversityEDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)INSTITUTION AND LOCATIONDEGREE(if applicable)YEAR(s)FIELD OF STUDYBeijing Agricultural University, Beijing, ChinaB.S.1982Animal ScienceUniversity of Edinburgh, Edinburgh, United KingdomPh.D.1987Molecular GeneticsWistar Institute, Philadelphia, PAPostdoc1992Cellular DifferentiationA.A. PositionsPositions andand Honors.Honors. PositionsPositions 1993-1995Research Associate, Immunology Program, Wistar Institute, Philadelphia, PA 1996 1999 Senior Scientist, Immunology Program, Wistar Institute, Philadelphia, PA 3/2000-3/2004Assistant Professor, Department of Microbiology and Immunology, Weill Medical College of Cornell University (WMCCU). 4/2004-09/2007 Associate Professor, Department of Microbiology and Immunology, (WMCCU). 12/2004-presentAssociate Director, Host Defenses Course, (WMCCU). 10/2007-presentProfessor with tenure, Department of Microbiology and Immunology, (WMCCU). 12/2007-presentDepartment of Pediatrics, faculty mentor for critical care medicine fellows (WMCCU). 9/2009-presentChairman, Admission to Candidacy Examination (ACE) Committee, Graduate Program in Immunology and Microbial Pathogenesis, Weill Graduate School of Medical Sciences, Cornell University. HonorsHonors 1983-1987Predoctoral Studentship from Tang Kakji Trust. 1985 1987 Overseas Student Award by the British Council. 1998 Young Investigators Award by International Cytokine Society. 1999-2004Howard Temin Award (NCI/NIH)EditorialEditorial ResponsibilitiesResponsibilities 2002-presentMember, Faculty 1000 (Immunology). 2002-presentAdvisory Editorial Board of the Journal of Experimental Medicine 2005-presentAdvisory Editorial Board of Annual Review of Biomedical Science 2007-present Editorial Board, Journal of the International Society of Interferon and Cytokine Research 07/2009-presentAssociate Editor, The Journal of Immunology 12/2009-presentAdvisory Editorial Board of Cellular and Molecular ImmunologyProfessionalProfessional MembershipMembership 2004-present American Association of Immunologists (AAI)2002-present International Society for Interferon and Cytokine Research B.B. SelectedSelected peer-reviewedpeer-reviewed publicationspublications (in(in reversereverse chronologicalchronological order)order)1. Lu, TT, Kim, H, MaMa, X X. 2011. IL-17, a new kid on the block of tertiary lymphoid organs. Mol.Mol. Cell.Cell. Immunol.Immunol. 2011 Sep 19. doi: 10.1038/cmi.2011.34. Epub ahead of print 2. Yin, F, Banerjee, R, Thomas, B, Zhou, P, Qian, L, Jia, T, Ma,Ma, X X, Ma, Y, Iadecola, C, Beal, MF, Nathan, C and Ding, H. 2010. Exaggerated Inflammation, Impaired Host Defense and Neuropathology in Progranulin- Deficient Mice. J.J. Exp.Exp. Med.Med. 207(1):117-128. 3. Jiao, X., Katiyar, S., Willmarth, NE, Liu, M., Flomenberg, N., Ma,Ma, X X., Lisanti, MP, Pestell, RG. 2010. C-jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion. J.J. Biol.Biol. Chem.Chem. 285(11):8218-8226. J.J. Immunol.Immunol. 184:3718-3724.5. Zhang, Y. Ma,Ma, X.X. 2010. Triptolide Inhibits IL-12/IL-23 Gene Expression in Antigen-presenting Cells via CCAAT/enhancer-Binding Protein Alpha. J.J. Immunol.Immunol. 184:3866-3877.NatureNature ImmunologyImmunology. 10(5):471-479.J Immunol. 2009 Jul 15;183(2):1110-1119.leishmania spp.-infected macrophages. J.J. Parasitol.,Parasitol., 94(1):8493.9. Chung, E., Liu, J., Homa, Y., Zhang,Y., Brendolan, A., Saggese, M., Han, J., Silverstein, R., Selleri, L., X.Ma.X.Ma. 2007. Interleukin-10 Expression in Macrophages during Phagocytosis of Apoptotic Cells Is Mediated by homeoproteins Pbx-1 and Prep-1. Immunity.Immunity. 27:952-964. 10.Liu, J., Guan, X., X.X. MaMa. 2007. Regulation of IL-27 p28 gene expression in macrophages through MyD88- and Interferon-mediated pathways. J J ExpExp MedMed. . 204:141-152. 11.Park-Min, K., Serbina, N., Yang, W., X.X. MaMa, Krystal, G., Neel, BJ, Nutt, SL, Hu, X., and Ivashkiv, LB. 2007.FcRIII-Dependent Inhibition of Interferon- Responses Mediates Suppressive Effects of Intravenous Immune Globulin. Immunity.Immunity. 26, 67-78. 12.Chung, EY, Liu, J., Zhang, Y., and X.X. Ma.Ma. 2007. Differential Expression in Lupus-associated IL-10 Promoter Single-nucleotide Polymorphisms Is Mediated by Poly(ADP-ribose) Polymerase 1. GenesGenes 795: 13-25.Ann N Y Acad Sci 1996; 795: 357-60.59.Chehimi J, MaMa X,X, Chouaib S, Zyad A, Nagashunmugam T, Wojcik L, Chehimi S, Nissim L Frank I. Differential production of interleukin 10 during human immunodeficiency virus infection. AIDSAIDS ResRes HumHum RetrovirusesRetroviruses 1996; 12: 1141-9. 60. Aste-Amezaga M, MaMa X X Trinchieri G. Regulation by interleukin-10 of Staphylococcus aureus- and lipopolysaccharide-induced interleukin-12 gene expression in human peripheral blood mononuclear cells. AnnAnn N N Y Y AcadAcad SciSci 1996; 795: 319-20. 61.MaMa X X, D'Andrea A, Kubin M, Aste-Amezaga M, Sartori A, Monteiro J, Showe L, Wysocka M Trinchieri G. Production of interleukin-12. ResRes ImmunolImmunol 1995; 146: 432-8. 62.D'Andrea A, MaMa X X, Aste-Amezaga M, Paganin C Trinchieri G. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production. J J ExpExp MedMed 1995; 181: 537-46. 63.Cassatella MA, Meda L, Gasperini S, D'Andrea A, MaMa X X Trinchieri G. Interleukin-12 production by human polymorphonuclear leukocytes. EurEur J J ImmunolImmunol 1995; 25: 1-5. 64.Chehimi J, Starr SE, Frank I, D'Andrea A, MaMa X X, MacGregor RR, Sennelier J Trinchieri G. Impaired interleukin 12 production in human immunodeficiency virus-infected patients. J J ExpExp MedMed 1994; 179: 1361-6. 65.MaMa X X, Saitoh N Curtis PJ. Purification and characterization of a nuclear DNA-binding factor complex containing topoisomerase II and chromosome scaffold protein 2. J J BiolBiol ChemChem 1993; 268: 6182-8. 66.D'Andrea A, Aste-Amezaga M, Valiante NM, MaMa X X, Kubin M Trinchieri G. Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma- production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J J ExpExp MedMed 1993; 178: 1041-8. 67.MaMa X X, Fraser P Curtis PJ. A differentiation stage-specific factor interacts with mouse carbonic anhydrase form I gene and a conserved sequence in mammalian beta-globin genes. DifferentiationDifferentiation 1991; 47: 135- 41. 68. Clark AJ, Chave-Cox A, MaMa X X. Bishop JO. Analysis of mouse major urinary protein genes: variation between the exonic sequences of group 1 genes and a comparison with an active gene out with group 1 both suggest that gene conversion has occurred between MUP genes. EMBOEMBO J J 1985; 4: 3167-71.Books, Book Chapters and Reviews1. Zhang, Y., Kim, HJ, Yamamoto, S., Kang, X., Ma,Ma, X. 2010. Regulation of Interleukin-10 Gene Expression in Macrophages Engulfing Apoptotic Cells. J.J. InterfronInterfron & & CytokineCytokine Res.Res. 30(3):1-9 2. Yamamoto, S., Ma,Ma, X.X. 2009. Role of Nod2 in the development of Crohns disease. MicrobesMicrobes andand Infection.Infection. 11(12):912-918. 3. Chung, E.Y., S.J. Kim, and X.J.X.J. Ma.Ma. 2006. Regulation of cytokine production during phagocytosis of apoptotic cells. CellCell ResRes 16:154-161. 4. Liu, J., Cao, S., Kim, S.J., Chung, E.Y., Homma, Y., Jimenez, V., Ma,Ma, X X. 2005. Interleukin-12: an update on its immunological activities, signaling and regulation of gene expression. CurrentCurrent ImmunologyImmunology ReviewsReviews 1:119-137. 5. Kim, S., E.Y. Chung, and X.X. MaMa. 2005. Immunological Consequences of Macrophage-Mediated Clearance of Apoptotic Cells. CellCell CycleCycle 4:231-234. 6. Kim, S.J., Gershov, D., Ma,Ma, X.,X., Brot, N., Elkon, E.L. 2003. Opsonization of Apoptotic Cells and its Effect on Macrophage and T cell Immune Responses. AnnAnn N N Y Y AcadAcad Sci.Sci. 987:68-78. 7. Xiang, Z., Yang, Y., Ma,Ma, X.,X., and Ding, W. 2003. Microarray Expression Profiling: Analysis and Applications. CurrentCurrent OpinionsOpinions inin DrugDrug DiscoveryDiscovery andand DevelopmentDevelopment 6(3):384-395. 8. Ma,Ma, X.X. 2001. TNF- and IL-12: a balancing act in macrophage functioning. MicrobesMicrobes andand InfectionInfection. Forum in Immunology: inhibitory receptors of mononuclear phagocytes. Institut Pasteur. 3(2):121-9. 9. Ma.Ma. X X. and Trinchieri G. 2001. Regulation of Interleukin-12 production in antigen-presenting cells. AdvancesAdvances inin ImmunologyImmunology. 79:55-92. 10. Ma.Ma. X.X. and Montaner, L.J. 2000. HIV-1 infection: proinflammatory response and IL-12 production by macrophages. J J LeukocLeukoc BiolBiol. 68(3):383-90. 11.Ma,Ma, X X., Reimann, H., Gri, G., and Trinchieri, G. 1998. Positive and negative regulation of Interleukin-12 gene expression. EurEur CytokineCytokine NetwNetw. 9(3 Suppl):54-64. 12.Neurath, M., Ma,Ma, X X., and Pettersson, S. (262 pages). 1997. DNA- protein interactions. Spectrum Akadenvischer Verlag, Heidelberg, Berlin, Oxford. 13. MaMa X X., Aste-Amezaga M, Gri G, Gerosa F, Trinchieri G. . 1997. Immunomodulatory functions and molecular regulation of IL-12. ChemChem ImmunolImmunol. 68:1-22. C.C. ResearchResearch GrantGrant SupportSupport CurrentCurrent1R01AI072149-01A21R01AI072149-01A2Ma (PI) 09/26/09-08/31/12NIH/NIAID“Crohn's disease-associated NOD2 Mutants”R01R01 AI083219AI083219 Murray (PI), Ma (co-PI) 02/05/10-01/31/15 NIH/NIAID“Immunochemotherapy in Visceral Leishmaniasis”1R56AI095512-01Ma (PI) 08/15/11-07/31/12NIH/NIAID“Regulation of IL-10 Gene Expression and Host Septic Response by Progranulin”KomenKomen BreastBreast CancerCancer FoundationFoundation Ma (PI) 06/01/09-05/31/12 “Role and mechanism of chemokine RANTES in immunity against breast cancer”CrohnsCrohns & & ColitisColitis FoundationFoundation ofof AmericaAmerica Ma (PI) 01/01/11-03/31/12 “Regulation of inflammatory cytokine expression by NOD2 via a novel winged helix/forkhead nuclear factor”CompletedCompleted withinwithin thethe pastpast threethree yearsyears: : R21 AT004349(PI: Ma) 09/30/07-08/31/09 NIH/NCCAM, “Mechanism of Modulation of Interleukin-12 Production by Triptolide” R01 AI045899(PI : Ma) 08/01/04-07/31/09 NIH/NIAID, “Cytokine Production during Phagocytosis of Apoptotic Cells” This project investigated how apoptotic cell-derived signals regulate IL-12 and IL-10 gene expression in professional phagocytes. R01 CA100223(PI: Ma)03/15/04-02/28/09 NIH/NCI, “Regulation of IL-12 Expression and Activity by Oncogenes”