Choice two of all questions from different teachers to answer in English and submit in 9th wk.doc
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1、Choice two of all questions from different teachers to answer in English and submit in 9th wk. (2009.10.16)1DNA was collected from 100 people randomly sampled from a given human population and was digested with the restriction enzyme BamH; the fragments were separated by electrophoresis and then tra
2、nsferred to a membrane filter using the Southern blot technique. The blots were probed with a particular cloned sequence. Three different patters of hybridization were seen on the blots. Some DNA samples (56 of them) showed a single band of 6.3kb, others (6) showed a single band of 4.1kb, and others
3、 (38) showed both the 6.3-and the 4.1-kb bands.a. Interpret these results in terms of BamHsites. b. What are the frequencies of the restriction site allele? c. Does this population appear to be in Hardy-Weinberg equilibrium for the relevant restriction site?2It is possible to create a zygote from tw
4、o copies of the maternal genome alone. In amphibians, the zygote will develop and mature into an adult without fertilization by a sperm cell (this process is known parthenogenesis). The same experiment has been attempted in mice, but it always results in early prenatal death. Explain this.3. Explain
5、 why 8% to 10% of female carriers of the DMD gene have muscle weakness or DMD phenotype.4. One member of a pair of MZ twins is affected by an autosomal dominant disease, and the other is not. List two different ways in which this could happen.5. The G6PD locus is located on the X chromosome. Studies
6、 of G6PD alleles in tumor cells from women show that all tumor cells usually express the same single G6PD allele, even though the women are heterozygous at the G6PD locus. What does this finding imply about the origin of the tumor cells?6. A pedigree for an autosomal dominant disease, each family me
7、mber has been typed for a four- allele microsatellite marker, as shown in the aoutradiogram below the pedigree. Determine linkage phase for the disease and marker locus in the affected male in generation . Based on the meioses that produced the offspring in generation , what is the recombination fre
8、quency for the marker and disease locus?7. Figure out the all possible offsprings from the couple which female with balanced reciprocal translocation of XX, t (2; 5) (q21; q31) and male with normal male karyotype after reading something. (only list zygote karyotype)8. DMD has a high mutation rate bu
9、t shows no ethnic variation in frequency. Use your knowledge of the gene and the genetics of DMD to suggest why this disorder is equally common in all populations.9. Inversions are known to affect crossing-over. The following homologs have the indicated gene order (the filled and open circles are ho
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