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1、1(摘自 45 度角 F3 http:/www.cc98.org/dispbbs.asp?BoardID=241 DOI: 10.1002/cncr.23867.Individuals with the BsmI polymorphism had a 30% increase in the odds ratio for melanoma, Simone Mocellin, M.D., Ph.D., and Donato Nitti, M.D., of the University of Padova, reported online in Cancer. Another vitamin D r
2、eceptor polymorphism previously implicated in melanoma had no association with the cancer. Data were inconclusive regarding three additional polymorphisms. “Current evidence is in favor of the association between one vitamin D receptor gene polymorphism and the risk of melanoma development, although
3、 further work will be necessary to validate the risk identified in the current meta-analysis,“ the authors concluded. A growing body of evidence suggests that vitamin D - specifically 1,25-dihydroxycholecaliciferol (1,25OH2D3) - has significant protective effects against cancer. Much of the interest
4、 in vitamin Ds anticancer potential centers on its role as a transcription factor involved in regulating cell growth, differentiation, and apoptosis, the authors said. Epidemiologic evidence has suggested an inverse association between sun exposure, serum levels of 1,25OH2D3, and vitamin D intake an
5、d the risk of developing or surviving cancer, they continued. “Because this vitamin exerts its function on engagement of its receptor . it is likely that polymorphisms of this nuclear hormone receptor family member affect the ability of interacting with its ligand, which ultimately would lead to dif
6、ferent levels of vitamin D biologic activity,“ said Drs. Mocellin and Nitti. Studies of specific polymorphisms have yielded conflicting results, and the total body of data had not been examined by meta-analytic techniques, they added. In an effort to fill in some of the gaps in the information, the
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