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1、学学 号:号:20141030200272014103020027姓姓 名:杨名:杨 靖靖The Signaling Pathways in Cerebral Ischemia-induced neurogenesisNeurogenesis in the adult brainSVZ: the subventricular zone.physiological Action: odor discrimination olfactory memeorySGZ: the subgranular zone.physiological Action: learning,memory and neur
2、opsychiatric disordersNeurogenesis in Cerebral Ischemianeural stem cells; neural progenitor cells; neuroblastsThe Shh Signaling Pathway in Ischemia-induced NeurogenesisThe Shh receptors Ptc and Smo are expressed in the adult hippocampus and in progenitors derived from this region.Exogenous Shh incre
3、ases neurogenesis in the SVZ.The Shh pathway also mediates stroke-induced neurogenesis.The miR-17-92 cluster in the Shh signaling pathway.The Shh Signaling Pathway in Ischemia-induced Neurogenesis The Notch Signaling Pathway in Cerebral Ischemia-induced NeurogenesisVarious studies have shown that co
4、mponents of the Notch pathway are expressed in the SVZ and SGZ of the adult mammalian brain.In the ischemic brain, activation of the Notch pathway increases neural progenitor cell proliferatio.miR-124a in the Notch signaling pathway.The Notch Signaling Pathway in Cerebral Ischemia-induced Neurogenes
5、isThe BMP Signaling Pathway in Cerebral Ischemia-induced NeurogenesisThe BMP Signaling Pathway and Noggin in Cerebral Ischemia-induced NeurogenesisBMPs are negatively regulated by Noggin.The Wnt Signaling Pathway in Cerebral Ischemia-induced NeurogenesisThe Wnt Signaling Pathway in Cerebral Ischemia-induced NeurogenesisSeveral studies have addressed the role of Wnt signaling in adult neurogenesis.Cerebral ischemia changes expression of Wnt and BMP family genes in SVZ neural progenitor cells.Neurotrophic factors in Cerebral Ischemia-induced Neurogenesis
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