Regulation of CHO Metabolism.ppt
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1、1,Regulationofglycolysis,1.WhenATPlevelsaresufficient,glycolysisactivitydecreasesHexokinaseinhibitedbyexcessglucose6-phosphatePFK-1isinhibitedbyATPandcitratePyruvatekinaseisinhibitedbyATP2.WhenATPisneeded,glycolysisisactivatedAMP(theproductofATPconsumption)relievetheinhibitionofPFK-1byATPFructose2,6
2、-bisphosphate(F2,6BP)relievetheinhibitionofPFK-1byATPPyruvatekinaseisactivatedbyF1,6BP,Step1,Step3,Step10,2,RegulationofHexokinase,HexokinasereactionismetabolicallyirreversibleG6P(product)levelsincreasewhenglycolysisisinhibitedatsitesfurtheralonginthepathwayG6PinhibitshexokinaseisozymesI,IIandIIItha
3、tareactiveatnormalglucoseconcentrations(Kmvalues10-6to10-4M)Glucokinase(hexokinaseIV,Km10-2M)formsG6Pintheliver(forglycogensynthesis)whenglucoseisabundant(activityismodulatedbyfructosephosphatesandaregulatoryprotein),3,RegulationofPFK-1,ATPisasubstrateandanallostericinhibitorofPFK-1AMPallosterically
4、activatesPFK-1byrelievingtheATPinhibition(ADPisalsoanactivatorinmammaliansystems)ChangesinAMPandADPconcentrationscancontrolthefluxthroughPFK-1Elevatedlevelsofcitrate(indicateamplesubstratesforcitricacidcycle)alsoinhibitPFK-1,4,RegulationofPFK-1byFructose2,6-bisphosphate(F2,6BP),F2,6-BPisapotentactiv
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