外泌体在肿瘤中的研究.pptx
《外泌体在肿瘤中的研究.pptx》由会员分享,可在线阅读,更多相关《外泌体在肿瘤中的研究.pptx(25页珍藏版)》请在得力文库 - 分享文档赚钱的网站上搜索。
1、外泌体在肿瘤研究中的应用,癌细胞作为受体,经典文献:,1.DendriticcellexosomesdirectlykilltumorcellsandactivatenaturalkillercellsviaTNFsuperfamilyligands;2.Aberrantlowexpressionofp85instromalfibroblastspromotesbreastcancercellmetastasisthroughexosome-mediatedparacrineWnt10b;3.ExosomeTransferfromStromaltoBreastCancerCellsRegula
2、tesTherapyResistancePathways;4.MicroRNAsTransferfromHumanMacrophagestoHepato-CarcinomaCellsandInhibitProliferation;,癌细胞作为供体,例:,1.CancerExosomesPerformCell-IndependentMicroRNABiogenesisandPromoteTumorigenesis;2.ExosomesSecretedunderHypoxiaEnhanceInvasivenessandStemnessofProstateCancerCellsbyTargeting
3、AdherensJunctionMolecules;3.CancerExosomesTriggerFibroblasttoMyofibroblastDifferentiation;4.Exosomederivedfromepigallocatechingallatetreatedbreastcancercellssuppressestumorgrowthbyinhibitingtumor-associatedmacrophageinfiltrationandM2polarization;5.Humantumorvirusutilizesexosomesforintercellularcommu
4、nication;6.MurineMammaryCarcinomaExosomesPromoteTumorGrowthbySuppressionofNKCellFunction;,应用:Thenovelbiomarkers,例:,1.ClinicalImpactofSerumExosomalMicroRNA-21AsaClinicalBiomarkerinHumanEsophagealSquamousCellCarcinoma;2.Glypican-1identifiescancerexosomesanddetectsearlypancreaticcancer;3.Double-strande
5、dDNAinexosomesanovelbiomarkerincancerdetection;4.ExosomallongnoncodingRNACRNDE-hasanovelserum-basedbiomarkerfordiagnosisandprognosisofcolorectalcancer;,应用:Therapy,例:,1.ExosomesderivedfromIL-12-anchoredrenalcancercellsincreaseinductionofspecificantitumorresponseinvitro;2.SystemicallyInjectedExosomesT
- 配套讲稿:
如PPT文件的首页显示word图标,表示该PPT已包含配套word讲稿。双击word图标可打开word文档。
- 特殊限制:
部分文档作品中含有的国旗、国徽等图片,仅作为作品整体效果示例展示,禁止商用。设计者仅对作品中独创性部分享有著作权。
- 关 键 词:
- 外泌体 肿瘤 中的 研究
限制150内