MedicinalMushrooms药用菌.pptx
《MedicinalMushrooms药用菌.pptx》由会员分享,可在线阅读,更多相关《MedicinalMushrooms药用菌.pptx(51页珍藏版)》请在得力文库 - 分享文档赚钱的网站上搜索。
1、2021/9/131Medicinal Mushrooms药用菌药用菌2021/9/1322021/9/133PrimaryStructureofBG一级结构Secondary二级结构Tertiary三级结构2021/9/134Importance of Tertiary Structure The Transistor is the Primary Structure The Circuit Board is the Secondary Structure The Computer is the Tertiary StructureInElectronics2021/9/135Terpeno
2、idsinMushrooms菌体中的萜类化合物Anti-infectious抗感染Anti-inflammatory抗炎2021/9/136MedicinalMushroomsandPrebiotics药用菌与益生元Mushroomsformaclassabovemanyotherprebiotics菌高于其它许多益生元类StimulateMcellsintheliningoftheintestine刺激在肠衬里的M细胞2021/9/137Ganoderma lucidum(Reishi,Lingzhi)灵芝灵芝 Bitter(terpenoids)苦(萜类)Traditionalindica
3、tions:CFS,传统指标:CFSDiabetes,cholesterol,Asthma糖尿病,胆固醇,哮喘VitCimprovesabsorption提高维生素C的吸收Protectsskinvs.UV(cancer),WBCvs.radiation.保护皮肤免受紫外线的伤害BringsTNF-,IL-1,IL-6toupperlimitofnormal(vs.cancer?)提升肿瘤坏死因子-,白介素1,白介素6的水平(抗癌?)2021/9/138IFFBenzieBioavailabilityrequiresAbsorptionDistributiontosite(s)ofutiliz
4、ation(viabloodplasma)Activeformtobepresentinviableamountsatthesesites2021/9/139IFFBenzieIn VivoStudy to Assess Bioavailability of Antioxidants in Green Tea,and Ganoderma lucidum(Lingzhi)nAcute post ingestion(up to 3h;placebo-controlled)1.1g*,n=103.3g,n=7Photo courtesy of NAMMEX400mlstronggreenteaBlo
5、odcollectedUrinecollectedAgentingested2021/9/1310IFFBenzieBioavailabilityofLingzhi(Ganoderma lucidum)Antioxidants*significantly(P0.05)different from time-matched level after placebo#significantly(P50ywithLUTS;dosesweregiven1xd.TheextractofG.lucidumwaswelltoleratedandanimprovementinInternationalProst
6、ateSymptomScoreIPSSwasobserved.TherecommendeddailydoseofG.luciduminmenwithLUTSis6mg.M.Noguchi对50位年逾50的LUTS男性患者进行随机、剂量探索、双盲安慰剂对照试验。结果:灵芝具有良好耐受性,能有效地改善患者的国际前列腺症状评分。建议LUTS男性患者每日服用的剂量为6毫克。NoguchiM,KakumaT,KuritaKet al.EffectofanextractofGanoderma luciduminmenwithlowerurinarytractsymptoms:adouble-blind,p
7、lacebo-controlledrandomizedanddose-rangingstudy.Asian J Androl2008;10:651-658.2021/9/1314ReishiMax as Anti-CancerTan NZ,Li CL,Sliva D,Zhang Y,Gao L,Zhu JS.Effects of Ganoderma lucidum extract ReishiMax on sarcoma S180-bearing mice and its synergy with green tea polyphenols Tegreen.National Symposium
8、 on Medicinal Fungi,Jiangxi,China 2008:165-171Ln TimeReishiMax 666 mg/kgPlaceboGrouping Variable:group RMKaplan-Meier Ln Cum.Hazard Plot for time RMCensor Variable:-3-2.5-2-1.5-1-.501.41.651.92.152.42.65Placebo0.20.80.81.01.21.41.61.82.02.22.42.62.8Reishi ExtractTumorWeight(g)2021/9/1315Cordyceps si
9、nensis冬虫夏草冬虫夏草Canbecookedwith:服用方法:-oldduck老鸭-black-bonehen乌骨鸡-leanpork(formen)瘦肉(男性)-quail鹌鹑-bakedabalone(bronchitis)鲍鱼(支气管炎)HalpernGM.Cordyceps:ChinasHealingMushroom.Avery,NY.1999;116pp2021/9/1316冬蟲夏草冬蟲夏草2021/9/13172021/9/1318Cordyceps sinensis 冬虫夏草冬虫夏草Formorethanathousandyears,Cordyceps sinensish
10、asbeenthemostprized“tonicfood”inAsia,especiallyinChina.冬虫夏草是中国传统的名贵药材,有逾千年的历史Cordyceps sinensiswasrecordedin“New Compilation of Materia Medica”as:在“本草从新”的记述中,虫草具备以下特质 sweetandneutralinnature味甘性温protectslungandkidneyfunction补肺益肾nourishestheessenceandvitalenergy滋养强壮具养生作用Cordyceps sinensis is primarily
11、akindof“parasiticmushroom”.Theprincipalspecies(主要种属)isPaecilomyces hepialiChen.冬虫夏草属寄生菌种,主要种属是Paecilomyces hepialiInthelate1970s,InstituteofMateriaMedica,Beijing,initiateda10-yearprogramtostudyCordyceps sinensis.中国医学科学院药物研究所于七十年代末期,对冬虫夏草展开了为期10年的研究计划Possiblebasisofeffect-adenosineanalogueandpolysacc
12、harides-Cs-1基本作用-腺苷类似物、多糖Cs-12021/9/1319Cordyceps sinensis(冬蟲草冬蟲草)Courtesy of Prof.F.T.Chau ABCTwavelengthretentiontimeintensity2021/9/1320SomeoftheuniquenucleosidesfoundinCordyceps 2021/9/1321 Historical 历史上历史上-Protectslungandkidneyfunction保护肝肾功能-Nourishestheessenceandvitalenergy滋养强壮具养生作用Current 現代
13、現代-Promotesstamina,healthylungfunction滋肺阴-Increasesendurance增加耐力-Reducesfatigue减少疲劳Dose 剂量剂量:525mgcapsule:2capsulestwiceorthreetimesdailywithfood每粒胶囊含有525 毫克,每天服用2-3 次Cordyceps Claims冬虫夏草冬虫夏草2021/9/1322 Cordyceps-Clinical studies冬虫夏草冬虫夏草-临床研究临床研究Humanstudies人类研究Highertolerancetocold(66elderlysubject
14、s)改善畏寒(66位长者)Improvementinfatiguedpatients(117subjects)改善体虚不复(117位患者)IncreasedSODlevels(37subjects)增加超氧化物歧化酶(SOD)水平(37位患者)Majoractivityvs.arrhythmias(75%improved)对抗心律失常(75%的患者)2021/9/1323Reference参考Cs-4 dos.剂量Weeks tt时间Total(n)总数Improved 改善%Han19953g/day2121009292%Quetal19953g/day4302687%Zheng&Deng1
15、9953g/day4201785%Yang19854.5g/day4272178%Zhengetal19854.5g/day4201890%Clinical Efficacy of Cs-4 in the Treatment of Respiratory DiseasesCs-4 对呼吸系统疾病的临床疗效对呼吸系统疾病的临床疗效 Clinicalimprovementnegativecontrols(p0.01)临床改善多于阴性对照(p0.20p0.20+13.7%p0.001CordyMaxCs-4ImprovesSteady-stateBio-EnergyStatusinMouseLive
16、rDaiG,BaoT,XuC,CooperR,ZhuJS.J Alt Compl Med2001;7:231-2402021/9/1329Treatment2.03.04.05.0Ratioofb-ATP:PiControl400mg/kg/d200mg/kg/d0714(Days)+47.7%+41.4%2021/9/1330100110120130140150160PlaceboCordyMaxSerum LDL(mg.dl-1)p=0.446-5.4%p=0.002 Week 0 Week 8 EffectsofCordyMaxonLipidsinPatientswithModerate
- 配套讲稿:
如PPT文件的首页显示word图标,表示该PPT已包含配套word讲稿。双击word图标可打开word文档。
- 特殊限制:
部分文档作品中含有的国旗、国徽等图片,仅作为作品整体效果示例展示,禁止商用。设计者仅对作品中独创性部分享有著作权。
- 关 键 词:
- MedicinalMushrooms 药用
限制150内