分子生物学分子生物学 (33).pdf
《分子生物学分子生物学 (33).pdf》由会员分享,可在线阅读,更多相关《分子生物学分子生物学 (33).pdf(17页珍藏版)》请在得力文库 - 分享文档赚钱的网站上搜索。
1、 Chapter 13 Gene Therapy 13.1 Basic strategies for gene therapy A new manner of clinical treatment that transfers certain genetic material into the patients cells and ensure it work in vivo to administrate the disease is called gene therapy.Concept of gene therapy 13.1 Basic strategies for 13.1 Basi
2、c strategies for gene therapygene therapy (1)Gene replacement(2)Gene augmentation(3)Gene interference(4)Suicide gene therapy(5)Gene immunotherapy(1)Gene replacement Definition:The introduction of specific target genes into specific cells,through the site-specific recombination,i.e.,the introduction
3、of normal gene to displace the original defective gene.Objective:To correct the abnormal sequence of defective genes.accurate in situ repair of defective sites of defective genes and does not involve any changes in the genome.Conditions of directional integration:vectors of transduction genes have t
4、he same sequence as genomic DNA.The vector with the target gene can find the site of homologous recombination and exchange some gene sequences,thus the treatment strategy works.Also known as gene targeting Gene homologous recombination Gene homologous recombination technologytechnology Defect genes
5、Normal gene Recombinant vector Normal gene Positioning and reorganization technology Chromosome Insertion Gene Homologous Recombination Technology Principle Animation(2)Gene augmentation Definition:Target cells express genes that are introduced to compensate for the innate gene dysfunction.Type:A.Th
6、e corresponding normal genes are introduced into the cells with defective genes.The defective genes in the cells are not removed,however,its function is compensated by the expressional products of the normal genes;B.The target gene introduced does not originally expressed in the cells.Definition:Use
- 配套讲稿:
如PPT文件的首页显示word图标,表示该PPT已包含配套word讲稿。双击word图标可打开word文档。
- 特殊限制:
部分文档作品中含有的国旗、国徽等图片,仅作为作品整体效果示例展示,禁止商用。设计者仅对作品中独创性部分享有著作权。
- 关 键 词:
- 分子生物学分子生物学 33 分子生物学 33
限制150内