5、消化系统肿瘤消化系统肿瘤 (11).pdf
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1、 Journal of Clinical Oncology List of Issues Volume 38,Issue 15_suppl Meeting Abstract|2020 ASCO Annual Meeting IGASTROINTESTINAL CANCERGASTROESOPHAGEAL,PANCREATIC,ANDHEPATOBILIARYPhase II study assessing tolerability,efficacy,and biomarkers for durvalumab(D)tremelimumab(T)and gemcitabine/cisplatinR
2、ights&PermissionsOPTIONS&TOOLSExport CitationTrack CitationAdd To FavoritesADVERTISEMENTADADVERTISEMENTLog InSubmitE-AlertsCartOpenAthens/Shibboleth MENU Article Tools(GemCis)in chemo-nave advanced biliarytract cancer(aBTC).Do-Youn Oh,Kyung-Hun Lee,Dae-Won Lee,Tae Yong Kim,Ju-Hee Bang,Ah-Rong Nam,.S
3、how MoreAbstract Disclosures4520Background:In aBTC,GemCis is the standard ofcare as 1-line treatment.Immunotherapies haveshown early promising efficacy in some BTCpatients(pts).We assessed D(anti-PD-L1)T(anti-CTLA-4)and GemCis in 1L BTC pts,includingan extensive biomarker analysis(NCT03046862).Metho
4、ds:Pts were first enrolled in the biomarkercohort(BMC)to receive 1 cycle of Gem 1000mg/m +Cis 25 mg/m on D1&D8,followed byGemCis+D 1120 mg and T 75 mg,Q3W untildisease progression(PD).Subsequent pts wereCOMPANION ARTICLESNo companion articlesARTICLE CITATIONDOI:10.1200/JCO.2020.38.15_suppl.4520Journ
5、al of Clinical Oncology 38,no.15_suppl(May 20,2020)4520-4520.Published online May 25,2020.WE RECOMMENDADVERTISEMENTEmployer:Merritt HawkinsApply for this job Employer:Potomac Oncology&HematologyApply for this job Hematology-Oncology OpportunityJust Outside of ChicagoRockford,Illinois N/AA reputable
6、integrated health system seekinga board-certified or board-eligiblehematologist-oncologist to join its team.Oncology&Hematology AssociatePositionRockville,Maryland Competitive SalaryThis position offers a competitive base salary,a comprehensive benefits package,exceptional productivity incentives,an
7、d apartnership track.Hematology/Oncology-at the Beach inLow Tax Delaware!Delaware(US);Family-oriented resort area inbeautiful south coastal DelawareAbstractst22Standard cisplatin/infusional 5-fluorouracil(PF)vs docetaxel(T)plusPF(TPF)as neoadjuvantchemotherapy for nonresectablelocally advanced squam
8、ous cellcarcinoma of the head andneck(LA-SCCHN):a phase III trial of theEORTC Head and Neck Cancer Group(EORTC#24971)J.B.Vermorken et al.,J Clin Oncol,2004Kinetics of Liquid Biopsies inPredicting Response toImmunotherapyPashtoon M.Kasi et al.,ASCO DailyNews,2020allocated to GemCis+D(3 combo cohort 3
9、C)orGemCis+D+T(4 combo cohort 4C)until PD.In allcohorts,tumor biopsies were obtained pre-treatment,after 1 cycle,and at PD.Blood samplesfor ctDNA were obtained every cycle.Results:121pts were enrolled.Median follow-up durationswere 28.5 months(m;95%CI,26.5-30.5),11.3 m(95%CI,9.1-13.5),and 11.9m(95%C
10、I,8.4-15.4)inthe BMC,3C,and 4C arms,respectively.Efficacydata are shown(Table).The most commonadverse events(AEs,any grade)were neutropenia(54.5%),nausea(59.5%),and pruritus(55.44%).The most common grade 3/4 AEs wereneutropenia(50.4%),anemia(35.5%),andthrombocytopenia(16.5%).In the BMC cohort,freque
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