test exampleVitamin D Receptor Polymorphism Linked to Melanoma.doc
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1、1Vitamin D Receptor Polymorphism Linked to MelanomaPADOVA, Italy, Sept. 22 - A polymorphism in the vitamin D receptor significantly increased the risk of melanoma, a meta-analysis of published data showed. Source reference: Mocellin S, Nitti D “Vitamin D receptor polymorphisms and the risk of cutane
2、ous melanoma“ Cancer 2008; DOI: 10.1002/cncr.23867.Individuals with the BsmI polymorphism had a 30% increase in the odds ratio for melanoma, Simone Mocellin, M.D., Ph.D., and Donato Nitti, M.D., of the University of Padova, reported online in Cancer. Another vitamin D receptor polymorphism previousl
3、y implicated in melanoma had no association with the cancer. Data were inconclusive regarding three additional polymorphisms. “Current evidence is in favor of the association between one vitamin D receptor gene polymorphism and the risk of melanoma development, although further work will be necessar
4、y to validate the risk identified in the current meta-analysis,“ the authors concluded. A growing body of evidence suggests that vitamin D - specifically 1,25- dihydroxycholecaliciferol (1,25OH2D3) - has significant protective effects against cancer. Much of the interest in vitamin Ds anticancer pot
5、ential centers on its role as a transcription factor involved in regulating cell growth, differentiation, and apoptosis, the authors said. Epidemiologic evidence has suggested an inverse association between sun exposure, serum levels of 1,25OH2D3, and vitamin D intake and the risk of developing or s
6、urviving cancer, they continued. “Because this vitamin exerts its function on engagement of its receptor . it is likely that polymorphisms of this nuclear hormone receptor family member affect the ability of interacting with its ligand, which ultimately would lead to different levels of vitamin D bi
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