《天然药化课件英》PPT课件.ppt
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1、 Natural Products Chemistry唐万侠唐万侠(Tang Wanxia)Natural Products ChemistryBilingual Teaching Methods1.Explain the knowledge in English and Chinese.2.Pay attention to the culture exchange in the world.3.Improve the ability to utilize specialty English.Natural Products ChemistryExamination for Natural P
2、roducts ChemistrySelective Course1.Come to the class on time:10 2.Behaviour in class:10 3.Class note:10 4.Examination at the end of the class:70 Note:Someone cant be allowed to come to the examination if he is absent from the class more than 6 times.Natural Products ChemistryClass ContentsChapter 1
3、IntroductionChapter 2 Saccharide and GlycosidesChapter 3 PhenylpropanoidsChapter 4 QuinonesChapter 5 FlavonoidsChapter 6 Terpenoids and Volatile oilsChapter 7 Triterpenoids and SaponinsChapter 8 Steroides and GlycosidesChapter 9 AlkaloidsChapter 10 Marine Natural Products糖和苷糖和苷苯丙素类化合物苯丙素类化合物醌类化合物醌类化
4、合物黄酮类化合物黄酮类化合物萜类和挥发油萜类和挥发油三萜及其苷类三萜及其苷类甾体及其苷类甾体及其苷类生物碱生物碱海洋天然药物海洋天然药物 Natural Products Chemistry 1、Outline3、Extract and isolation methods4、Structural elucidation methods2、BiosynthesisChapter 1 Introduction Natural Products Chemistry1、OutlineDefinition:Natural products chemistry is a subject to resear
5、ch the chemical constituents of natural medicinal plants on the base of modern scientific theory and methods.Contents:Structural characteristics,physicochemical properties,extract and isolation methods,and structural elucidation of the chemical constituents of all kinds of natural medicinal plants.N
6、atural Products ChemistryResearch resource:Natural plants(major),animals,minerals,and microorganism.1、OutlineNatural medicinal plants herb medicine Natural Products Chemistry麻黄麻黄(Ephedra spp.)1、Outline Natural Products Chemistry1、Outline Natural Products Chemistry槐花米槐花米(Sophora japonica)1、Outline 1、
7、Outline Natural Products ChemistryDevelopments in foreign countries In 1769,tartar(potassium hydrogen tartrate)was transferred to calcium salt and decomposed in sulphuric acid to produce tartaric acid.(K.W.Schelle,Swedish)In 1804,morphine was isolated from opium(Dorosine,French)In 1806,morphine was
8、isolated from opium(Serturner,German)In 1810-1860,the period of alkaloid development1、Outline Natural Products ChemistrySpectroscopic analysis:NMR,MS,IR,and UV.Research methods:extract and isolation guided by bioactive scanning,structural modification,and total synthesis.1、OutlineDevelopment of nowa
9、days Natural Products Chemistry 1、Outline3、Extract and isolation methods4、Structural elucidation methods2、BiosynthesisChapter 1 Introduction Natural Products Chemistry2、BiosynthesisCO2H2O葡萄糖代谢葡萄糖代谢磷酸烯醇式丙酮酸磷酸烯醇式丙酮酸丙酮酸丙酮酸乙酰辅酶乙酰辅酶A丙二酸甲酰辅酶丙二酸甲酰辅酶A甲羟戊酸甲羟戊酸萜类萜类甾类甾类胡萝卜素类胡萝卜素类4-磷酸磷酸脂肪酸类脂肪酸类前列腺素类前列腺素类脂肪族及芳脂肪
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