SCI写作高大上句型1000例-4.pdf
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1、1 SCI写作高大上句型写作高大上句型1000例例301400301、But,inlightoftheunpromisingresultsduringXXX302、Hence,continuedrecommendationofsupplementationwithsuchvitaminsisdifficulttojustify.Instead,themainemphasisshouldbeonthosetreatments(eg,aspirin,statins,angiotensinconvertingenzymeinhibitors,_blockers,andantihypertensive
2、therapy)thataredefinitelyknowntopreventheartattacks,strokes,andotheradverseoutcomes.303、Thelackofbenefitofantioxidantvitaminsinseverallargerandomisedtrialscontradictstheclaimsfromobservationalstudiesthatsuggestedprotectionagainstcardiovasculardisease304、Thesefindingsemphasisetheneedtogenerallyviewcl
3、aimsoftreatmentbenefitfromobservationalstudieswithconsiderablescepticism,unlessconfirmedbylargewelldesignedrandomisedtrials.305、Therefore,the potential gains from the combination of currently knownpreventivestrategiesarelarge.Giventhatover80%ofcardiovasculardiseaseoccursin developing countries,a pri
4、ority is to make these interventions affordable,accessible,andconvenient(perhapsevenacombinationpill).Ensuringthatpatientsworldwidereceivethesetreatmentswillleadtosubstantialclinicalandpublichealthbenefits.306、.studyshowthelackofefficacyofVEinpreventingthevascularcomplications.wereunderrepresentedin
5、thecurrentstudy307、greatstrideshavebeenmadeintheuseofvariouspharmacologicinterventionsforthetreatmentofpatientswithcardiovasculardisease.308、Theirfindingsdemonstrateasignificantbenefitassociatedwiththe.,addingtothegrowingbodyofevidencethatsupportsinstitutingdrugtherapythattargets309、This study prese
6、nts intriguing information in.First,it demonstratesthat.becauseof.,itisimportanttonotethat2 310、Because oxidative processes are important in the development ofatherosclerosis,supplementation has been proposed for the treatment andpreventionofcoronarydisease.311、.supplementationinconjunctionwith.trea
7、tmentwasassociatedwithareducedrateofprogressionofcoronaryarterylesions312、However,enthusiasm for the use of supplemental vitamin E has recentlydecreasedinthelightofothertrialsdemonstratingnobeneficialeffect.Also,theuseofmaybedeleterious.313、Inthelightofprevioustrials,alimitationofthisstudyisitsuseof
8、amixedregimenofa314、Althoughantioxidanttherapydoesnotappeartobeusefulinpatientswith.,thepossibilitythatitmayhaveabenefitinotherpatientswithcardiovasculardiseasehasnotbeenexcluded.315、Althoughintriguing,theseresultscannotbeextrapolatedtootherpopulations,Primarypreventionsettings,orotherlipidalteringc
9、ombinations,especiallyinthelightoftherecentconcernaboutthesideeffectsofstatins.316、However,thesedatademonstratetheimportanceoftargeting.andsupporttheconclusionthatalargerstudyiswarranted.317、Althoughthisstudycannotcompletelyrefuteclaimsthatothercombinationsofantioxidanttreatmentsareusefulindistinctp
10、opulations,thefindingsaddtothegrowing body of evidence that certain supplemental antioxidant regimens havelimitedbenefitinpatientswithcardiovasculardisease.318、Ourfindingsinvitroandinvivosupporttheinterpretationthat.319、Dissection of mechanisms of Chinese medicinal formula.as an effectivetreatmentfo
11、r320、Toenhancetherapeuticefficacyandreduceadverseeffects,practitionersoftraditionalChinesemedicine(TCM)prescribeacombinationof.basedonclinical3 Experience321、.buttheworkingmechanismsofmostremainunknown.322、Intryingtoaddressthepossiblebeneficialeffectsof.withcurrentbiomedicalapproaches,weuse.,whichha
12、sbeenproventobeveryeffectiveintreating.323、Here,wereportthattheATVincombinationwith.TSNyieldssynergyinthetreatmentofApoEdeficientatherosclerosispronemodelinvivoandinmacrophagefoamcellformationinvitro.324、.causedintensified.andenhancedthroughhittingmultipletargetscomparedwiththeeffectofmonotherapy.Fu
13、rthermore,.intensifiedtheexpressionofandfacilitate.which in turn enhances.and therapeutic efficacy.Our data alsoindicate.as.325、WethereforesuggestthatdissectingthemodeofactionofclinicallyeffectiveTCM at the molecular,cellular,and organism levels may be a good strategy inexploringthevalueoftraditiona
14、lmedicineandexplorethecombinationtherapybetweenTCMandwesternmedicine.326、Increasingevidencedemonstratesthat,intreatingillnesses,includingcoronaryheartdisease(literature)cancer(1)andHIV/AIDS(2),treatmentregimenscontainingmultiple drugs with distinct but related mechanisms can usually amplify thethera
15、peuticefficaciesofeachagent,leadingtomaximaltherapeuticefficacywithminimaladverseeffects.327、whereasprecisemechanismsofformulaeremaintobeaddressedbyusingmolecularapproaches328、Theliteraturedocumentstheantitumoractivity.329、Theseresultsnotonlydemonstratetheclinicalefficacyof,butalsosuggestthepossible
16、synergisticeffects.warrantingthemechanisticexplorationofthisformula.330、IntryingtoapproachtherationaleofformuladesigninTCM,hereweusethetreatmentofAPLwithRIFasaworkingmodel.efficaciesandmechanismsofATI4 combinationonAPLweretestedinvivoandinvitro.331、InVivoTherapeuticEfficaciesof.onaMurineASModel.332、
17、Inthepastfewyears,thepharmaceuticalindustryhasseenashiftfromthesearchformagicbulletsthatspecificallytargetasinglediseasecausingmoleculetothepursuitofcombinationtherapiesthatcomprisemorethanoneactiveingredient333、OneexampleisRIF,whoseefficaciesintreatingAPLhavebeenwellestablishedrecently.334、Inthisst
18、udy,wefindthat,inamurineASmodel,combineduseoftheactivecomponentsofRIF,namelyA,T,andI,significantly335、TheseresultsclearlyshowthatcomponentsofRIFexerteffectsofmutualreinforcement.However,ATIdoesnotshowanintensifiedadverseeffectintheAPLmurinemodel,asrevealedbychangeinbodyweight,consistentwiththesafety
19、ofRIFobservedintheclinic.Theseobservationsareinagreementwiththerationalityoftheformula:mutualreinforcementofthecompoundsandreductionofadverseeffects.336、Alargebodyofevidenceindicatesthat.isthecausative337、Inthisstudy,theATIcombinationisfoundtobeabletoactonsomekeytranscriptionfactors.338、Finally,itis
20、worthpointingoutthat,intheprincipleofdesigningaformulainTCM,.339、Itmaybeaninterestingobservationinthisworkthat340、Thisphenomenonnotonlysuggeststhatbutalsoindicatesthatformulaemightexerttherapeuticeffectsthroughmechanismsbeyondeachcomponent.341、Of note,in untreated.These results suggest that AQP9 med
21、iates,to asignificantextent,thetherapeuticeffectsof,andthatmightassist.intheformulathroughmodulatingthiskeytransporter.342、attenuate/slow/retardtheprogressionofcoronaryAS343、Inthelightof.alimitationofthestudyistheuseof.ratherthan.5 344、Ascomparedwithlipidalteringtherapyalone,thecombineduseoflipidalt
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