SCI写作高大上句型1000例-3.pdf
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1、1 SCI写作高大上句型写作高大上句型1000例例201300201、representapromisingalternativeforthefuturebecauseof.202、Weinvestigatedtheassociationbetween203、Usingdatafromthe.whichassessedtheimpactofwesoughttoexplorepotentialmechanismsunderlyingthisadverseoutcome204、ThemainstayoftreatmentforASremainspharmacological;however,cat
2、heterablationhasincreasinglybeenusedoverthelastdecade.Therelativemeritsofeachstrategyhavenotbeenextensivelystudied.205、Despitefavorableeffectsonhighdensitylipoproteincholesterol(HDLC)andlowdensity lipoprotein cholesterol,the cholesteryl ester transfer protein inhibitortorcetrapibfailedtoslowatherosc
3、lerosisprogressionandincreasedmortality.Weinvestigated the relationship between lipid changes and progression of coronaryatherosclerosis.206、Futurestudieswith.inhibitorswithoutofftargettoxicityareneededtosettlethisissue207、Thisstudyisthefirsttoexaminetheeffectofdirect.stimulationon.withtheuseoftheno
4、vel.receptoragonistcompound21208、Treatment with.was assessed bywere analyzed for inflammation andapoptosiswithimmunoblottingandrealtimereversetranscriptionpolymerasechainreaction.significantlyimproved.Inregardtounderlyingmechanisms,diminished.indicatinganantiapoptoticeffect.Phosphorylationofthep44/4
5、2andp38mitogenactivatedproteinkinases,bothinvolvedintheregulationofcellsurvival,wasstronglyreducedafterMIbutalmostcompletelyrescuedbyC21treatment.Furthermore,.decreased.aswellascardiacinterleukin6,interleukin1,andinterleukin2expression,suggestinganantiinflammatoryeffect.209、Directstimulationmaybeano
6、veltherapeuticapproachtoimprovebyantiapoptoticandantiinflammatorymechanisms.2 210、However,itsunderlyingmechanismofantiadipogeniceffectsremainsunknown211、NewresearcheffortshavebeguntoexplorethepotentialutilityofPPARantagoniststodelivertherapeuticbenefitwithreducedsideeffectprofiles.212、Toexaminewheth
7、ertheobservedeffectofTaninthesuppressionofwasmediatedthroughthePPARpathway213、thusitisreasonabletopostulatethat.However,thepossibleeffectsofTanonothertissuesawaitfurtherinvestigation.214、ThestudywarrantsfurtherinvestigationtoexploretherapeuticpotentialofTaninmetabolicDisorders.215、.tothisend.216、Exp
8、erimentalandclinicaldataindicatethatstatinsmayconfercardiovascularbenefitsinadditiontothelipidloweringactivityatleastpartlybymodulatingtheinflammatoryarmofatherosclerosis.Wethereforeexaminedtheabilityofstatinstomodulate.expressionin.byanalyzingtheeffectofsimvastatin(20mgqd)andatorvastatin(80mgqd)on.
9、expression217、Inthepresentstudy,weshowdisturbedregulationofthehomeostatic218、Althoughseveraladditionalexperimentswillhavetobeperformed,basedonrecentstudies,itistemptingtohypothesizethatthedifferentexpressionpatternofXXX219、Thefindingsinthepresentstudysuggestthatthesemoleculesalsocouldbeinvolvedinthe
10、XXX220、Ifsuchmechanismsalsoareoperatingwithintheatheroscleroticlesion,theymayin addition to promotingan inflammatory Th1 phenotype,also induce a matrixdegrading,inflammatory,andprothromboticphenotype221、.areknowntohavepersistentlyincreasedlevelsourfindingcouldbeofrelevancealsoinrelationtofurthersupp
11、ortingsuchanotion222、However,2veryrecentarticleshavesuggestedthat.mayplayanimportant3 roleinemigrationofTcellsfrominflamedtissuewithparticularlypronouncedeffecton.223、by.,andbyinducingamatrixdegrading,prothrombotic,andinflammatoryphenotypeinmacrophages,thesechemokinescouldcontributetoatherogenesisan
12、dplaquedestabilization,possiblyrepresentingnoveltargetsfortherapyinCAD224、Recentstudiessuggestthatthebeneficialeffectsofstatinsinatheroscleroticdisordersmayberelatedtotheirimmunomodulatoryproperties.Hereinweshowthatthesedrugsareableto.225、Tofurtherelucidatethisissue,weexamined.Tofurthercharacterize.
13、226、Evidencefromclinicalandexperimentalstudiessupportsapathogenicroleforinflammationinatherosclerosis.Thisincreasingappreciationoftheimportanceofinflammationinatherogenesishasfocusedattentiononmoleculesthatdirect.227、Weperformedstudiesinpatientswith.andhealthycontrols,invitrostudiesinTcellsandmacrop
14、hages,andstudiesinapolipoproteinEdeficient(ApoE/)miceandhumanatheroscleroticcarotidplaques.228、Theadventof(HMGCoA)reductaseinhibitors,orstatins,hasrevolutionizedthetreatment of hypercholesterolemia due to competitive inhibition of HMGCoAreductase,theratelimitingenzymethatcatalyzesthedenovocholestero
15、lbiosynthesis.Inadditionagrowingbodyofevidencesuggeststhatstatinsexertbeneficialvasculareffectsthatareindependentoftheircholesterolloweringpotencies229、Themechanismsunderlyingtheseserumlipidindependenteffectsofstatinsarenotcompletelyunderstood,butthereisincreasingevidencethat.230、.inthedevelopmentof
16、atherosclerosisisstillundergoingdebate231、Therefore,theaimofthisstudywastoevaluatewhetherthestatininducedincreasePreviously,wedemonstratedthat.232、Thus,conflictingresultsareavailableforthesemousemodelsofatherosclerosisregardingtheeffectsofstatinsonatherogenesis.4 233、Tothebestofourknowledgetheeffect
17、ofstatinsonatherogenesisinapoE/LDLRdeficientmicehasnotbeenstudied.Thus,theaimofthisstudywastoevaluatewhetheratorvastatinpossesseshypolipidemicandantiinflammatoryeffectsinthesemice.Weanalyzedlipidprofileandinflammatorymarkersinbloodandtogetherwithexpressionofinflammatorymarkersandlesionsizeintheblood
18、vesselwall.234、butstudiesinvestigatingthepotentiallyadditiveeffectsofacombinedtreatmentstrategyarerare.Wehypothesisedthat235、However,themechanismsforitsregulationremainelusive236、revealingLpPLA2asanexcitingnewdrugtargetforthepreventionofseriouscardiovasculardisease.237、This study provides compelling
19、 evidence that inhibition of.blocks thedevelopmentofunstableplaquesbyreducingthegenerationofproinflammatorylipids.238、Theconceptthatatherosclerosisisachronicinflammatorydiseasehasnowgainedwideacceptanceinthefieldofcardiovascularresearch.239、Despitetheaccumulatingcircumstantialevidencepointingto.asac
20、ulpritinunstableplaqueformation,definitiveproofhasbeenlacking.240、.aneffectthatwascompletelyabrogatedinthedarapladibtreatedgroup241、Whatremainstobeestablishediswhetherselectiveinhibitionofreducesvulnerableplaqueformationinhumansand,ultimately,theincidenceofheartattackandstroke.242、Theseincreaseswere
21、significantlyreducedinadosedependentmannerbycotreatment with No cytotoxic effects of were observed under the sameexperimentalconditionsasassessedbylactatedehydrogenasereleaseandMTTassay.243、Severalepidemiologicalstudiesandinterventiontrialshavebeenperformedwith.andsomeofthemshowedthatitpreventsather
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